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Hou et al (2005) researched the autonomic effects of modafinil in humans. They identified that modafinil impacts the locus coeruleus, which mediates pupil diameter and arousal, but it does not have an effect on other autonomic capabilities, that are managed by noreadrenergic Regulate facilities (A1 – A5) Found beyond the locus coeruleus.Ferraro e
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